Recent topics in catalytic asymmetric hydrogenation of ketones
نویسندگان
چکیده
منابع مشابه
Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones
Optically active alcohols are important building blocks in the synthesis of fine chemicals, pharmaceuticals, agrochemicals, flavors and fragrances as well as functional materials (Arai & Ohkuma, 2011; Klingler, 2007). Furthermore, molecular hydrogen is without doubt the cleanest reducing agent, with complete atom efficiency. Therefore, the catalytic, asymmetric hydrogenation (AH) of prochiral k...
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[reaction: see text]. A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and up to 92.2% ee was obtained.
متن کاملCatalytic asymmetric hydrogenation of naphthalenes.
The catalytic asymmetric hydrogenation of heteroarenes has been intensively studied during the last decade. Nowadays, various heteroaromatics, for example, indoles, pyrroles, and quinolines, can be reduced to the corresponding chiral heterocycles with high stereoselectivity through asymmetric catalysis. Glorius and co-workers recently found that a chiral N-heterocyclic carbene–ruthenium catalys...
متن کاملCatalytic Asymmetric Hydrogenation of Heteroarenes
INTRODUCTION Asymmetric hydrogenation of unsaturated organic compounds has been established as one of the most efficient methods for the preparation of chiral, non-racemic substrates. Among hydrogenation of various substrates, the asymmetric hydrogenation of heteroarenes provides a straightforward approach to a wide range of enantiomerically pure saturated heterocycles, which are subunits of ma...
متن کاملPhosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones
Novel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is a-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design al...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2014
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2014.04.129